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Tetrahydroaminoacridine potentiates neurotoxicity of quinolinic acid in rat striatum.

Authors
  • Zhu, S G
  • McGeer, E G
  • Singh, E A
  • McGeer, P L
Type
Published Article
Journal
Neuroscience Letters
Publisher
Elsevier
Publication Date
Dec 19, 1988
Volume
95
Issue
1-3
Pages
252–256
Identifiers
PMID: 2976129
Source
Medline
License
Unknown

Abstract

Intraperitoneal injection of 5 mg/kg of tetrahydro-9-amino-acridine (THA) in rats 1 h before intrastriatal injection of 50-150 nmol of quinolinic acid potentiated the local neurotoxicity as indicated by measurements of striatal levels of glutamate decarboxylase and choline acetyltransferase. A larger dose (10 mg/kg) THA had no significant effect. The results are discussed in terms of THA's binding to various elements of the NMDA/sigma receptor complex and reported data on such binding are confirmed.

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