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Tetracycline Antibiotics Induce Host-Dependent Disease Tolerance to Infection

Authors
  • Colaço, Henrique G.1
  • Barros, André1
  • Neves-Costa, Ana1
  • Seixas, Elsa1
  • Pedroso, Dora1
  • Velho, Tiago1
  • Willmann, Katharina L.1
  • Faisca, Pedro1
  • Grabmann, Gerlinde2
  • Yi, Hyon-Seung3
  • Shong, Minho3
  • Benes, Vladimir4
  • Weis, Sebastian5, 6, 7
  • Köcher, Thomas2
  • Moita, Luís F.1, 8
  • 1 Instituto Gulbenkian de Ciência, Rua da Quinta Grande 6, 2780-156 Oeiras, Portugal
  • 2 Vienna BioCenter Core Facilities GmbH, 1030 Vienna, Austria
  • 3 Research Center for Endocrine and Metabolic Diseases, Chungnam National University School of Medicine, Daejeon 35015, Korea
  • 4 EMBL Genomics Core Facilities, D-69117 Heidelberg, Germany
  • 5 Institute for Infectious Diseases and Infection Control, Jena University Hospital, 07747 Jena, Germany
  • 6 Department of Anesthesiology and Intensive Care Medicine, Jena University Hospital, 07747 Jena, Germany
  • 7 Center for Sepsis Control and Care, Jena University Hospital, 07747 Jena, Germany
  • 8 Instituto de Histologia e Biologia do Desenvolvimento, Faculdade de Medicina, Universidade de Lisboa, Portugal
Type
Published Article
Journal
Immunity
Publication Date
Jan 12, 2021
Volume
54
Issue
1
Pages
53–67
Identifiers
DOI: 10.1016/j.immuni.2020.09.011
PMID: 33058782
PMCID: PMC7840524
Source
PubMed Central
Keywords
License
Unknown

Abstract

Several classes of antibiotics have beneficial effects on the outcome of infections that cannot be explained by their direct antibacterial activities alone. Colaço et al. show that inhibition of mitochondrial protein synthesis by ribosomal-targeting antibiotics perturbs the mitochondrial electron transport chain and induces disease tolerance to infection.

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