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Testing two models describing how methylome-wide studies in blood are informative for psychiatric conditions.

Authors
  • Aberg, Karolina A
  • Xie, Lin Y
  • McClay, Joseph L
  • Nerella, Srilaxmi
  • Vunck, Sarah
  • Snider, Sarah
  • Beardsley, Patrick M
  • van den Oord, Edwin J C G
Type
Published Article
Journal
Epigenomics
Publisher
Future Medicine
Publication Date
Aug 01, 2013
Volume
5
Issue
4
Pages
367–377
Identifiers
DOI: 10.2217/epi.13.36
PMID: 23895651
Source
Medline
License
Unknown

Abstract

Our results show that, consistent with the signature model, factors that affect brain processes (i.e., haloperidol) leave biomarker signatures in the blood and, consistent with the mirror-site model, the methylation status of many sites in the blood mirror those in the brain.

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