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Testing for fluoxymesterone (Halotestin) administration to man: identification of urinary metabolites by gas chromatography-mass spectrometry.

Authors
  • Kammerer, R C1
  • Merdink, J L
  • Jagels, M
  • Catlin, D H
  • Hui, K K
  • 1 Paul Ziffren Olympic Analytical Laboratory, UCLA Department of Pharmacology, School of Medicine 90024.
Type
Published Article
Journal
Journal of steroid biochemistry
Publication Date
Aug 28, 1990
Volume
36
Issue
6
Pages
659–666
Identifiers
PMID: 2214783
Source
Medline
Language
English
License
Unknown

Abstract

Fluoxymesterone, an anabolic steroid, is metabolized in man primarily by 6 beta-hydroxylation, 4-ene-reduction, 3-keto-reduction, and 11-hydroxy-oxidation. These pathways of metabolism are suggested by the positive identification of 4 metabolites and the tentative identification of 3 other metabolites. Detection of the drug in urine is possible for at least 5 days after a single 10 mg oral dose to previously untreated adult males, by monitoring the presence of 2 metabolites, since the parent drug is not detectable more than 1 day after the dose.

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