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Testicular microvascular flow is altered in Klinefelter syndrome and predicts circulating testosterone.

Authors
  • Carlomagno, Francesco1
  • Pozza, Carlotta1
  • Tenuta, Marta1
  • Pofi, Riccardo1
  • Tarani, Luigi1
  • Sesti, Franz1
  • Minnetti, Marianna1
  • Gianfrilli, Daniele1
  • Isidori, Andrea M1
  • 1 Department of Experimental Medicine, Sapienza University of Rome, Rome.
Type
Published Article
Journal
The Journal of Clinical Endocrinology & Metabolism
Publisher
The Endocrine Society
Publication Date
Aug 18, 2021
Identifiers
DOI: 10.1210/clinem/dgab605
PMID: 34407199
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Experimental studies on Klinefelter syndrome (KS) reported increased intratesticular testosterone (T) levels coexisting with reduced circulating levels. Abnormalities in testicular microcirculation have been claimed; however, no studies investigated in vivo testicular blood flow dynamics in humans with KS. To analyze the testicular microcirculation in KS by contrast-enhanced ultrasonography (CEUS) and correlate vascular parameters with endocrine function. Prospective study. University Setting. 68 testicular scans, 34 testes from 19 T-naïve subjects with KS and 34 testes from age-matched eugonadal men (CNT) who underwent CEUS for incidental nonpalpable testicular lesions.Main Outcomes. CEUS kinetic parameters. CEUS revealed slower testicular perfusion kinetics in subjects with KS than in age-matched CNT. Specifically, the wash-in time (Tin, p = 0.018), mean transit time (MTT, p = 0.035), time to peak (TTP, p < 0.001), and washout time (Tout 50%, p = 0.004) were all prolonged. Faster testicular blood flow was associated with higher total T levels. Principal component analysis and multiple linear regression analyses confirmed the findings, and supported a role for reduced venous blood flow as independent predictor of total T levels. Testicular venous blood flow is altered in KS and independently predicts T peripheral release. © The Author(s) 2021. Published by Oxford University Press on behalf of the Endocrine Society. All rights reserved. For permissions, please e-mail: [email protected]

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