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A Test-and-Not-Treat Strategy for Onchocerciasis in Loa loa-Endemic Areas.

Authors
  • Kamgno, Joseph1
  • Pion, Sébastien D1
  • Chesnais, Cédric B1
  • Bakalar, Matthew H1
  • D'Ambrosio, Michael V1
  • Mackenzie, Charles D1
  • Nana-Djeunga, Hugues C1
  • Gounoue-Kamkumo, Raceline1
  • Njitchouang, Guy-Roger1
  • Nwane, Philippe1
  • Tchatchueng-Mbouga, Jules B1
  • Wanji, Samuel1
  • Stolk, Wilma A1
  • Fletcher, Daniel A1
  • Klion, Amy D1
  • Nutman, Thomas B1
  • Boussinesq, Michel1
  • 1 From the Center for Research on Filariasis and other Tropical Diseases (J.K., H.C.N.-D., R.G.-K., G.-R.N., P.N., J.B.T.-M.) and the Faculty of Medicine and Biomedical Sciences, University of Yaounde I (J.K.), Yaounde, and the Faculty of Health Sciences, Department of Microbiology and Parasitology, University of Buea, and Research Foundation for Tropical Diseases and Environment (REFOTDE), Buea (S.W.) - all in Cameroon; Institut de Recherche pour le Développement Unité Mixte Internationale 233-INSERM Unité 1175, Montpellier University, Montpellier, France (S.D.P., C.B.C., M.B.); the Department of Bioengineering and the Biophysics Program, University of California, Berkeley, Berkeley (M.H.B., M.V.D., D.A.F.); the Department of Pathobiology and Diagnostic Investigation, Michigan State University, East Lansing (C.D.M.); the Department of Public Health, Erasmus MC, University Medical Center, Rotterdam, the Netherlands (W.A.S.); the Chan Zuckerberg Biohub, San Francisco (D.A.F.); and the Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, MD (A.D.K., T.B.N.). , (Cameroon)
Type
Published Article
Journal
New England Journal of Medicine
Publisher
New England Journal of Medicine
Publication Date
Nov 23, 2017
Volume
377
Issue
21
Pages
2044–2052
Identifiers
DOI: 10.1056/NEJMoa1705026
PMID: 29116890
Source
Medline
License
Unknown

Abstract

The LoaScope-based test-and-not-treat strategy enabled the reimplementation of community-wide ivermectin distribution in a heretofore "off limits" health district in Cameroon and is a potentially practical approach to larger-scale ivermectin treatment for lymphatic filariasis and onchocerciasis in areas where L. loa infection is endemic. (Funded by the Bill and Melinda Gates Foundation and others.).

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