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Teratogenic effect of an inhibitor of cholesterol synthesis (AY 9944) in rats: correlation with maternal cholesterolemia.

Authors
  • Roux, C
  • Dupuis, R
  • Horvath, C
  • Talbot, J N
Type
Published Article
Journal
The Journal of nutrition
Publication Date
Nov 01, 1980
Volume
110
Issue
11
Pages
2310–2312
Identifiers
PMID: 6159463
Source
Medline
License
Unknown

Abstract

The teratogenic action of AY 9944, an inhibitor of cholesterol synthesis, was previously shown. Its prevention by simultaneous administration of cholesterol led to the hypothesis that this action is correlated with the decrease in cholesterol. The present investigation demonstrates that there is an inverse correlation between holoprosencephalic type of malformations and maternal cholesterolemia and that, in Wistar rats, 0.30 g/liter of cholesterolemia is a threshold under which these malformations can be observed.

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