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Tenofovir-based rescue therapy for advanced liver disease in 6 patients coinfected with HIV and hepatitis B virus and receiving lamivudine.

Authors
  • Gutiérrez, Sonia
  • Guillemi, Silvia
  • Jahnke, Natalie
  • Montessori, Valentina
  • Harrigan, P Richard
  • Montaner, Julio S G
Type
Published Article
Journal
Clinical Infectious Diseases
Publisher
Oxford University Press
Publication Date
Feb 01, 2008
Volume
46
Issue
3
Identifiers
DOI: 10.1086/525857
PMID: 18181733
Source
Medline
License
Unknown

Abstract

We summarize the clinical history and laboratory results following the introduction of tenofovir among 6 patients coinfected with human immunodeficiency virus (HIV) and hepatitis B virus (HBV) who presented with severe liver disease while receiving lamivudine-based highly active antiretroviral therapy. In all cases, the introduction of tenofovir led to a sustained undetectable HBV and HIV loads, with marked clinical and laboratory improvement in liver function. We provide supporting evidence for the role of tenofovir in the management of advanced HBV infection in HIV-positive patients after the development of lamivudine resistance.

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