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Tendon and ligament mechanical loading in the pathogenesis of inflammatory arthritis

Authors
  • Gracey, Eric1, 2
  • Burssens, Arne1, 3
  • Cambré, Isabelle1, 2
  • Schett, Georg4, 5
  • Lories, Rik6
  • McInnes, Iain B.7
  • Asahara, Hiroshi8, 9
  • Elewaut, Dirk1, 2
  • 1 Ghent University, Ghent, Belgium , Ghent (Belgium)
  • 2 Ghent University Hospital, Ghent, Belgium , Ghent (Belgium)
  • 3 Universitair Ziekenhuis Gent, University of Ghent, Ghent, Belgium , Ghent (Belgium)
  • 4 Friedrich-Alexander University Erlangen-Nuremberg, Erlangen, Germany , Erlangen (Germany)
  • 5 Universitätsklinikum Erlangen, Erlangen, Germany , Erlangen (Germany)
  • 6 KU Leuven, Leuven, Belgium , Leuven (Belgium)
  • 7 University of Glasgow, Glasgow, UK , Glasgow (United Kingdom)
  • 8 The Scripps Research Institute, San Diego, CA, USA , San Diego (United States)
  • 9 Graduate School of Medical and Dental Sciences, Tokyo, Japan , Tokyo (Japan)
Type
Published Article
Journal
Nature Reviews Rheumatology
Publisher
Springer Nature
Publication Date
Feb 20, 2020
Volume
16
Issue
4
Pages
193–207
Identifiers
DOI: 10.1038/s41584-019-0364-x
Source
Springer Nature
License
Yellow

Abstract

Mechanical loading is a biological stressor that elicits a homeostatic response to ensure the health and survival of the cells and/or tissues it is applied to. Tissues that encounter high amounts of mechanical stress are prone to damage, especially the tendon and ligament entheses.The immune system is crucial in responding to and orchestrating the repair of damaged tendons and ligaments.Mechanical loading is a well-defined factor in the immunopathology of tendon and ligament disorders such as tendinopathy.Mechanical loading is associated with the onset of chronic inflammatory arthritis, including spondyloarthritis (SpA) and rheumatoid arthritis (RA).Microdamage associated with mechanical loading potentially focuses systemic autoimmune disease on the joint in the initiating phases of SpA and RA.

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