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Temporal changes in interpapillary muscle dynamics as an active indicator of mitral valve and left ventricular interaction in ischemic mitral regurgitation.

Authors
  • Kalra, Kanika
  • Wang, Qian
  • McIver, Bryant V
  • Shi, Weiwei
  • Guyton, Robert A
  • Sun, Wei
  • Sarin, Eric L
  • Thourani, Vinod H
  • Padala, Muralidhar
Type
Published Article
Journal
Journal of the American College of Cardiology
Publication Date
Nov 04, 2014
Volume
64
Issue
18
Pages
1867–1879
Identifiers
DOI: 10.1016/j.jacc.2014.07.988
PMID: 25444139
Source
Medline
Keywords
License
Unknown

Abstract

By using cardiac magnetic resonance imaging in humans, we demonstrated that it is the impairment of lateral shortening between the papillary muscles, and not passive ventricular size, that governs the severity of mitral regurgitation. Loss of lateral shortening of IPMD tethers the leaflet edges and impairs their systolic closure, resulting in mitral regurgitation, even in small ventricles. Understanding the lateral dynamics of ventricular-valve interactions could aid the development of new repair techniques for ischemic mitral regurgitation.

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