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Tempol selectively attenuates angiotensin II evoked vasoconstrictor responses in spontaneously hypertensive rats.

Authors
  • Shastri, Shailesh
  • Gopalakrishnan, Venkat
  • Poduri, Ramarao
  • Di Wang, Hui
Type
Published Article
Journal
Journal of Hypertension
Publisher
Ovid Technologies (Wolters Kluwer) - Lippincott Williams & Wilkins
Publication Date
Jul 01, 2002
Volume
20
Issue
7
Pages
1381–1391
Identifiers
PMID: 12131535
Source
Medline
License
Unknown

Abstract

These data suggest that increased superoxide anions mediate vasoconstrictor responses to Ang II, but not to other agonists, in an endothelium-dependent manner, by quenching vasodilatory mediator, nitric oxide. This may account for the exaggerated vasoconstrictor responses to Ang II in SHRs.

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