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Tempol selectively attenuates angiotensin II evoked vasoconstrictor responses in spontaneously hypertensive rats.

Authors
Type
Published Article
Journal
Journal of Hypertension
0263-6352
Publisher
Ovid Technologies (Wolters Kluwer) - Lippincott Williams & Wilkins
Publication Date
Volume
20
Issue
7
Pages
1381–1391
Identifiers
PMID: 12131535
Source
Medline
License
Unknown

Abstract

These data suggest that increased superoxide anions mediate vasoconstrictor responses to Ang II, but not to other agonists, in an endothelium-dependent manner, by quenching vasodilatory mediator, nitric oxide. This may account for the exaggerated vasoconstrictor responses to Ang II in SHRs.

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