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Temperature-dependent viscosity dominated transport control through AQP1 water channel.

Authors
  • Kwang-Hua, Chu W1
  • 1 Transfer Centre, 2/F, 16, Lane 21, Guang-Hui Road, Taipei 116, Taiwan, China; Distribution Centre, Golmud Mansion, 33, Road Yingbin, Golmud 816000, China. Electronic address: [email protected] , (China)
Type
Published Article
Journal
Journal of Theoretical Biology
Publisher
Elsevier
Publication Date
Nov 07, 2019
Volume
480
Pages
92–98
Identifiers
DOI: 10.1016/j.jtbi.2019.08.006
PMID: 31400345
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

We give a supplementary explanation for previous results about the exclusion of proton as well as hydronium (ion) transport through aquaporins (AQP1) via verified transition state theory by calculating the temperature-dependent viscosity for proton or hydronium (ion) transport through AQP1. We will demonstrate the temperature-dependent viscosity dominated transport control in AQP1 via the selected activation energy as well as the activation volume considering the presumed wavy-roughness along the sub-nano domains. Our numerical results show that once proton or hydronium (ion) transport through AQP1 at room temperature behaves like a molecular fluid with a relatively high viscosity, such as pitch, then proton or hydronium (ion) transport through AQP1 will be blocked (like a solid). Otherwise, proton or hydronium (ion) transport through AQP1 at room temperature manifests like a molecular fluid with a correspondingly lower viscosity, such as water (H2O), and then exclusion of proton or hydronium (ion) through AQP1 will not occur. We also demonstrate possible size effect in blocking proton or hydronium (ion) transport through AQP1. Our predicted results are new and novel as there are no temperature-dependent viscosity measurements relevant to AQP1 yet. Copyright © 2019 Elsevier Ltd. All rights reserved.

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