Affordable Access

Access to the full text

Telomere-related Markers for Cancer

Authors
  • Yuan, Xiaotian1
  • Dai, Mingkai2, 2
  • Xu, Dawei3, 2
  • 1 Shandong University, Jinan , 250012
  • 2 Shandong University Second Hospital, Jinan , 250033
  • 3 ; , (Sweden)
Type
Published Article
Journal
Current Topics in Medicinal Chemistry
Publisher
Bentham Science Publishers
Publication Date
Mar 01, 2020
Volume
20
Issue
6
Pages
410–432
Identifiers
DOI: 10.2174/1568026620666200106145340
PMID: 31903880
PMCID: PMC7475940
Source
PubMed Central
Keywords
License
Green

Abstract

Telomeres are structurally nucleoprotein complexes at termini of linear chromosomes and essential to chromosome stability/integrity. In normal human cells, telomere length erodes progressively with each round of cell divisions, which serves as an important barrier to uncontrolled proliferation and malignant transformation. In sharp contrast, telomere maintenance is a key feature of human malignant cells and required for their infinite proliferation and maintenance of other cancer hallmarks as well. Thus, a telomere-based anti-cancer strategy has long been suggested. However, clinically efficient and specific drugs targeting cancer telomere-maintenance have still been in their infancy thus far. To achieve this goal, it is highly necessary to elucidate how exactly cancer cells maintain functional telomeres. In the last two decades, numerous studies have provided profound mechanistic insights, and the identified mechanisms include the aberrant activation of telomerase or the alternative lengthening of telomere pathway responsible for telomere elongation, dysregulation and mutation of telomere-associated factors, and other telomere homeostasis-related signaling nodes. In the present review, these various strategies employed by malignant cells to regulate their telomere length, structure and function have been summarized, and potential implications of these findings in the rational development of telomere-based cancer therapy and other clinical applications for precision oncology have been discussed.

Report this publication

Statistics

Seen <100 times