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Telomere length of in vivo expanded CD4(+)CD25 (+) regulatory T-cells is preserved in cancer patients.

Authors
  • Wolf, Dominik
  • Rumpold, Holger
  • Koppelstätter, Christian
  • Gastl, Guenther A
  • Steurer, Michael
  • Mayer, Gert
  • Gunsilius, Eberhard
  • Tilg, Herbert
  • Wolf, Anna M
Type
Published Article
Journal
Cancer immunology, immunotherapy : CII
Publication Date
Oct 01, 2006
Volume
55
Issue
10
Pages
1198–1208
Identifiers
PMID: 16362412
Source
Medline
License
Unknown

Abstract

Increased frequencies of Treg in peripheral blood of cancer patients are due to active proliferation rather than due to redistribution from other compartments (i.e., secondary lymphoid organs or bone marrow). In vivo expansion does not further shorten telomere length, probably due to induction of telomerase activity. In contrast, under conditions of strong in vitro stimulation telomerase induction seems to be insufficient to avoid progressive telomere shortening.

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