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Telomere length and heavy-chain mutation status in familial chronic lymphocytic leukemia.

Authors
  • Ishibe, Naoko
  • Prieto, DaRue
  • Hosack, Douglas A
  • Lempicki, Richard A
  • Goldin, Lynn R
  • Raffeld, Mark
  • Marti, Gerald E
  • Caporaso, Neil E
Type
Published Article
Journal
Leukemia Research
Publisher
Elsevier
Publication Date
Sep 01, 2002
Volume
26
Issue
9
Pages
791–794
Identifiers
PMID: 12127552
Source
Medline
License
Unknown

Abstract

We examined whether telomere lengths of peripheral blood mononuclear cells are associated with immunoglobulin gene usage in 21 familial chronic lymphocytic leukemia (CLL) patients. Subjects with unmutated V genes tended to have shorter telomeres than those with somatic mutations, especially after adjusting for age. Unlike V(H) mutation status, telomere length was not predictive for survival. Our results suggest that telomere length is associated with V(H) gene mutation status and provides further evidence that the biological basis of familial B-CLL is similar to that of sporadic patients.

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