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Telomerase unplugged.

Authors
  • Cristofari, Gaël
  • Sikora, Katarzyna
  • Lingner, Joachim
Type
Published Article
Journal
ACS Chemical Biology
Publisher
American Chemical Society
Publication Date
Mar 20, 2007
Volume
2
Issue
3
Pages
155–158
Identifiers
PMID: 17373762
Source
Medline
License
Unknown

Abstract

The control of telomerase activity at chromosome ends by telomere-binding proteins is critical for telomere length homeostasis. Two recent papers identify TPP1 as a critical mediator of this control. TPP1 forms part of the telomeric shelterin complex while also associating with telomerase, stimulating its activity and processivity.

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