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Telomerase-specific oncolytic adenovirus: antitumor effects on radiation-resistant head and neck squamous cell carcinoma cells.

Authors
  • Takahashi, Hideaki
  • Hyakusoku, Hiroshi
  • Horii, Chihiro
  • Takahashi, Masahiro
  • Nishimura, Goshi
  • Taguchi, Takahide
  • Kondo, Norio
  • Sakakibara, Atsuko
  • Urata, Yasuo
  • Sano, Daisuke
Type
Published Article
Journal
Head & neck
Publication Date
Mar 01, 2014
Volume
36
Issue
3
Pages
411–418
Identifiers
DOI: 10.1002/hed.23309
PMID: 23728900
Source
Medline
Keywords
License
Unknown

Abstract

Combined OBP-301 and radiation therapy seems to overcome radioresistance in HNSCC cells by inhibiting DNA repair machinery, and may thus be a novel therapeutic strategy for treating HNSCC.

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