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Telomerase activity in patients with transitional cell carcinoma: a preliminary study.

Authors
  • Rahat, M A1
  • Lahat, N
  • Gazawi, H
  • Resnick, M B
  • Sova, Y
  • Ben-Ari, G
  • Cohen, M
  • Stein, A
  • 1 Immunology Research Unit, Lady Davis Carmel Medical Center, Haifa, Israel.
Type
Published Article
Journal
Cancer
Publication Date
Feb 15, 1999
Volume
85
Issue
4
Pages
919–924
Identifiers
PMID: 10091771
Source
Medline
License
Unknown

Abstract

In this study, almost all tumor biopsies exhibited telomerase activity. The high incidence of telomerase activity found in cup biopsies of the malignant field uroepithelial cells from cup biopsies of TCC patients may suggest that telomerase could be activated early in carcinogenesis. A high incidence of telomerase activity was found in voided uroepithelial cells of TCC patients; however, no correlation between this activity and the histologic determination of grading and staging of the tumor was found.

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