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TCRBV12 genes are polymorphic but the protein products encoded by each gene are conserved.

Authors
  • Deulofeut, H
  • Wilderson, J L
  • Barron, K S
  • Robinson, M A
Type
Published Article
Journal
Human Immunology
Publisher
Elsevier
Publication Date
Jul 01, 1995
Volume
43
Issue
3
Pages
227–230
Identifiers
PMID: 7558940
Source
Medline
License
Unknown

Abstract

The human TCRBV gene complex contains three BV12 genes and all are polymorphic. There are two alleles of BV12S4; one allele contains a stop codon in the coding region which precludes its expression. There are four alleles of BV12S2 and two alleles of BV12S3 genes; however, the substitutions present in both genes are conservative. Although allelic variants exist for each of the three BV12 genes, only one protein product is encoded by each gene.

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