TCRBV12 genes are polymorphic but the protein products encoded by each gene are conserved.
- Published Article
- Publication Date
Jul 01, 1995
The human TCRBV gene complex contains three BV12 genes and all are polymorphic. There are two alleles of BV12S4; one allele contains a stop codon in the coding region which precludes its expression. There are four alleles of BV12S2 and two alleles of BV12S3 genes; however, the substitutions present in both genes are conservative. Although allelic variants exist for each of the three BV12 genes, only one protein product is encoded by each gene.
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The corresponding record at NLM can be accessed at https://www.ncbi.nlm.nih.gov/pubmed/7558940