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TAVR in Patients with Pure Aortic Regurgitation: Ready to Use?

Authors
  • Markham, Ryan1
  • Ghodsian, M.2
  • Sharma, R.1
  • 1 Stanford University, 300 Pasteur Drive, 3rd Floor, Room A31, Stanford, CA, 94305, USA , Stanford (United States)
  • 2 Wollongong Hospital, Loftus St, Wollongong, NSW, 2500, Australia , Wollongong (Australia)
Type
Published Article
Journal
Current Cardiology Reports
Publisher
Springer-Verlag
Publication Date
Jul 28, 2020
Volume
22
Issue
9
Identifiers
DOI: 10.1007/s11886-020-01338-6
Source
Springer Nature
Keywords
License
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Abstract

Purpose of the ReviewModerate or severe aortic regurgitation (AR) occurs in 0.5% of the population and typically peaks in the fourth to sixth decade of life. A significant proportion of patients have prohibitive surgical risk and are therefore treated medically with pharmacological management of heart failure and no definitive treatment of the underlying valvular pathology.Recent FindingsTranscatheter aortic valve replacement (TAVR) has been used in an off-label setting to treat AR to attempt to reduce mortality and improve quality of life with varying levels of success. New-generation TAVR devices currently used in AS have demonstrated safety and feasibility when used in patients with AR. Novel TAVR devices dedicated for use in AR are being developed and early studies demonstrate promising results.SummaryOngoing studies with larger clinical trials and novel methods of device anchoring are required, which if positive, will in turn lead to commercial approval and reimbursement, eventually making TAVR ready for use in AR.

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