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Tat-Vaccinated Macaques Do Not Control Simian Immunodeficiency Virus SIVmac239 Replication

Authors
Publisher
American Society for Microbiology
Publication Date
Source
PMC
Keywords
Disciplines
  • Biology
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Unknown

Abstract

The regulatory proteins of human immunodeficiency virus may represent important vaccine targets. Here we assessed the role of Tat-specific cytotoxic T lymphocytes (CTL) in controlling pathogenic simian immunodeficiency virus SIVmac239 replication after using a DNA-prime, vaccinia virus Ankara-boost vaccine regimen. Despite the induction of Tat-specific CTL, there was no significant reduction in either peak or viral set point compared to that of controls.

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