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Tat-Vaccinated Macaques Do Not Control Simian Immunodeficiency Virus SIVmac239 Replication

Authors
  • Todd M. Allen
  • Lorenzo Mortara
  • Bianca R. Mothé
  • Max Liebl
  • Peicheng Jing
  • Briana Calore
  • Marian Piekarczyk
  • Richard Ruddersdorf
  • David H. O'Connor
  • X. Wang
  • Chenxi Wang
  • David B. Allison
  • John D. Altman
  • Alessandro Sette
  • Ronald C. Desrosiers
  • Gerd Sutter
  • David I. Watkins
Publisher
American Society for Microbiology
Publication Date
Apr 01, 2002
Source
PMC
Keywords
Disciplines
  • Biology
License
Unknown

Abstract

The regulatory proteins of human immunodeficiency virus may represent important vaccine targets. Here we assessed the role of Tat-specific cytotoxic T lymphocytes (CTL) in controlling pathogenic simian immunodeficiency virus SIVmac239 replication after using a DNA-prime, vaccinia virus Ankara-boost vaccine regimen. Despite the induction of Tat-specific CTL, there was no significant reduction in either peak or viral set point compared to that of controls.

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