Affordable Access

deepdyve-link
Publisher Website

Task-dependent modulation of amygdala connectivity in social anxiety disorder.

Authors
  • Minkova, Lora1
  • Sladky, Ronald2
  • Kranz, Georg S3
  • Woletz, Michael2
  • Geissberger, Nicole2
  • Kraus, Christoph3
  • Lanzenberger, Rupert3
  • Windischberger, Christian4
  • 1 MR Center of Excellence, Center for Medical Physics and Biomedical Engineering, Medical University of Vienna, Austria; Department of Psychiatry and Psychotherapy, University Medical Center Freiburg, Germany; Freiburg Brain Imaging Center, University Medical Center Freiburg, Germany. , (Austria)
  • 2 MR Center of Excellence, Center for Medical Physics and Biomedical Engineering, Medical University of Vienna, Austria. , (Austria)
  • 3 Department of Psychiatry and Psychotherapy, Medical University of Vienna, Austria. , (Austria)
  • 4 MR Center of Excellence, Center for Medical Physics and Biomedical Engineering, Medical University of Vienna, Austria. Electronic address: [email protected] , (Austria)
Type
Published Article
Journal
Psychiatry research
Publication Date
Apr 30, 2017
Volume
262
Pages
39–46
Identifiers
DOI: 10.1016/j.pscychresns.2016.12.016
PMID: 28226306
Source
Medline
Keywords
License
Unknown

Abstract

Increased amygdala activation is consistently found in patients suffering from social anxiety disorder (SAD), a psychiatric condition characterized by an intense fear of social situations and scrutiny. Disruptions in the amygdalar-frontal network in SAD may explain the inability of frontal regions to appropriately down-regulate amygdalar hyper-activation. In this study, we measured 15 SAD patients and 15 healthy controls during an affective counting Stroop task with emotional faces to assess the interaction of affective stimuli with a cognitive task in SAD, as well as to investigate the causal interactions between the amygdala and the medial orbitofrontal cortex (OFC) using dynamic causal modeling (DCM). Here we show for the first time that differences in OFC-amygdala effective connectivity between SAD patients and healthy controls are influenced by cognitive load during task processing. In SAD patients relative to controls dysfunctional amygdala regulation was observed during passive viewing of harsh faces This could be linked to ongoing self-initiated cognitive processes (such as rumination and anticipation of negative events) that hinder successful amygdala regulation. However, between-group differences diminished during cognitive processing, suggesting that attentional load interfered with emotional processing in both patients and controls.

Report this publication

Statistics

Seen <100 times