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Targeting myelomonocytic cells to revert inflammation-dependent cancer promotion.

Authors
  • Colombo, Mario P
  • Mantovani, Alberto
Type
Published Article
Journal
Cancer research
Publication Date
Oct 15, 2005
Volume
65
Issue
20
Pages
9113–9116
Identifiers
PMID: 16230363
Source
Medline
License
Unknown

Abstract

Tumor development and progression are strongly linked to inflammation and the presence of tumor-associated macrophages (TAMs). In murine tumors, antitumor activity can be achieved by targeting TAM recruitment, survival, activation, polarization, effector signaling, or extracellular matrix interactions. Thus, it may be possible to increase the efficacy of conventional cancer therapeutic strategies by targeting TAMs.

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