Affordable Access

deepdyve-link
Publisher Website

Targeting MEX3A attenuates metastasis of breast cancer via β-catenin signaling pathway inhibition.

Authors
  • Wang, Yun1
  • Liang, Qian1
  • Lei, Kefeng2
  • Zhu, Qingqing1
  • Zeng, Delong3
  • Liu, Yuhong2
  • Lu, Yingsi1
  • Kang, Tingting1
  • Tang, Nannan4
  • Huang, Lifen4
  • Ye, Liping1
  • Tang, Di2
  • Zhu, Chengming5
  • 1 Scientific Research Center, The Seventh Affiliated Hospital, Sun Yat-sen University, Shenzhen, 518107, China. , (China)
  • 2 Department of General Surgery, The Seventh Affiliated Hospital, Sun Yat-sen University, Shenzhen, China. , (China)
  • 3 Department of Clinical Immunology, Institute of Laboratory Medicine, Guangdong Provincial Key Laboratory of Medical Molecular Diagnostics, School of Medical Technology, Guangdong Medical University, Dongguan, 523808, China. , (China)
  • 4 Division of Hematology/Oncology, Department of Pediatrics, The Seventh Affiliated Hospital, Sun Yat-sen University, Shenzhen, China. , (China)
  • 5 Scientific Research Center, The Seventh Affiliated Hospital, Sun Yat-sen University, Shenzhen, 518107, China. Electronic address: [email protected] , (China)
Type
Published Article
Journal
Cancer letters
Publication Date
Aug 21, 2021
Volume
521
Pages
50–63
Identifiers
DOI: 10.1016/j.canlet.2021.08.022
PMID: 34425185
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Metastasis is the major cause of mortality in patients with breast cancer. Understanding the metastatic mechanism to guide clinical diagnoses and the treatment of breast cancer remains a challenge. We found that the expression of Mex-3 RNA binding family member A (MEX3A) was upregulated significantly and related to tumor grade in breast cancer. The results of in vitro and in vivo studies showed that knockdown of MEX3A inhibited the metastasis and impaired the stemness of breast cancer cells. Furthermore, activation of the β-catenin signaling pathway was discovered as a molecular intermediate of MEX3A-mediated regulation. We also found that ectopic expression of β-catenin restored the migration ability, invasion ability, and CD44+/CD24- percentage of MDA-MB-231 and BT549 cells when MEX3A was depleted. In addition, we revealed that MEX3A positively regulated the expression of β-catenin by downregulating Dickkopf WNT signaling pathway inhibitor 1 (DKK1) expression. Therefore, a previously undiscovered role of MEX3A comprising a critical contribution to promoting metastasis and maintaining the stemness of breast cancer via the Wnt/β-catenin pathway was demonstrated in the present study. Copyright © 2021. Published by Elsevier B.V.

Report this publication

Statistics

Seen <100 times