Targeting a key enzyme in cell growth: a novel therapy for cancer.
- Published Article
- Publication Date
Oct 01, 1997
The enzyme ribonucleotide reductase (RR) controls the synthesis of DNA precursors and thus plays a pivotal role in cell growth. Since the free-radical-containing active-site of this enzyme can be disabled by a lone electron, low-level direct electric current should have an inhibitory effect on RR and, thus, on uncontrolled cell proliferation. This hypothesis is strongly supported by the results of several cancer electrotherapy studies reported over the years.
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The corresponding record at NLM can be accessed at https://www.ncbi.nlm.nih.gov/pubmed/9352497