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Targeting connexins: possible game changer in managing neuropathic pain?

Authors
  • Su, Yixun1
  • Verkhratsky, Alexei2
  • Yi, Chenju3
  • 1 Research Centre, Seventh Affiliated Hospital of Sun Yat-sen University, Shenzhen, China. , (China)
  • 2 Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, UK; Achucarro Center for Neuroscience, IKERBASQUE, Bilbao, Spain; Department of Stem Cell Biology, State Research Institute Centre for Innovative Medicine, Vilnius, Lithuania; Department of Forensic Analytical Toxicology, School of Forensic Medicine, China Medical University, Shenyang, China. Electronic address: [email protected]. , (China)
  • 3 Research Centre, Seventh Affiliated Hospital of Sun Yat-sen University, Shenzhen, China; Guangdong Provincial Key Laboratory of Brain Function and Disease, Guangzhou, China; Shenzhen Key Laboratory of Chinese Medicine Active substance screening and Translational Research, Shenzhen, China. Electronic address: [email protected]. , (China)
Type
Published Article
Journal
Trends in molecular medicine
Publication Date
Jul 01, 2024
Volume
30
Issue
7
Pages
642–659
Identifiers
DOI: 10.1016/j.molmed.2024.03.009
PMID: 38594094
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Neuropathic pain is a chronic debilitating condition caused by nerve injury or a variety of diseases. At the core of neuropathic pain lies the aberrant neuronal excitability in the peripheral and/or central nervous system (PNS and CNS). Enhanced connexin expression and abnormal activation of connexin-assembled gap junctional channels are prominent in neuropathic pain along with reactive gliosis, contributing to neuronal hypersensitivity and hyperexcitability. In this review, we delve into the current understanding of how connexin expression and function contribute to the pathogenesis and pathophysiology of neuropathic pain and argue for connexins as potential therapeutic targets for neuropathic pain management. Copyright © 2024 Elsevier Ltd. All rights reserved.

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