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Targeting cancer stem cells with dietary phytochemical - Repositioned drug combinations

Authors
  • Chan, Marion M.1
  • Chen, Rensa1, 2
  • Fong, Dunne2
  • 1 Department of Microbiology and Immunology, Lewis Katz School of Medicine, Temple University, 3400 North Broad Street, Philadelphia, PA, 19140, USA
  • 2 Department of Cell Biology and Neuroscience, Rutgers, The State University of New Jersey, 604 Allison Road, Piscataway, NJ, 08854, USA
Type
Published Article
Journal
Cancer letters
Publication Date
Jun 28, 2018
Volume
433
Pages
53–64
Identifiers
DOI: 10.1016/j.canlet.2018.06.034
PMID: 29960048
PMCID: PMC7117025
Source
PubMed Central
Keywords
License
Unknown

Abstract

• Cancer stem cells (CSCs) are the culprits for cancer drug resistance and cancer relapse. • Dietary phytochemicals (curcumin, resveratrol, epigallocatechin gallate) target CSCs. • Repositioned drugs (metformin, niclosamide, thioridazine) target CSCs. • Phytochemical-drug combinations targeting CSCs may exhibit synergistic effects.

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