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Targeting the brain: rationalizing the novel methods of drug delivery to the central nervous system.

Authors
  • Joshi, Shailendra
  • Ornstein, Eugene
  • Bruce, Jeffrey N
Type
Published Article
Journal
Neurocritical care
Publication Date
Jan 01, 2007
Volume
6
Issue
3
Pages
200–212
Identifiers
PMID: 17572864
Source
Medline
License
Unknown

Abstract

Drug delivery to the brain has remained one of the most vexing problems in translational neuroscience research. This review rationalizes the strategies to target drugs to the brain. Factors such as the speed of intervention, the scale of intervention, the state of BBB, and the permissible risks, will all be critical in deciding how best to deliver drugs to a target site in the brain for a specific clinical situation.

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