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Targeting Aquaporin-4 Subcellular Localization to Treat Central Nervous System Edema

Authors
  • Kitchen, Philip1
  • Salman, Mootaz M.2, 3, 4
  • Halsey, Andrea M.5
  • Clarke-Bland, Charlotte1
  • MacDonald, Justin A.6
  • Ishida, Hiroaki7
  • Vogel, Hans J.6, 7
  • Almutiri, Sharif5, 8
  • Logan, Ann5
  • Kreida, Stefan9
  • Al-Jubair, Tamim9
  • Winkel Missel, Julie10
  • Gourdon, Pontus10, 11
  • Törnroth-Horsefield, Susanna9
  • Conner, Matthew T.12
  • Ahmed, Zubair5
  • Conner, Alex C.13
  • Bill, Roslyn M.1
  • 1 School of Life & Health Sciences, Aston University, Aston Triangle, Birmingham B4 7ET, UK
  • 2 Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA
  • 3 Program in Cellular and Molecular Medicine, Boston Children’s Hospital, Boston, MA 02115, USA
  • 4 Department of Pharmacology, College of Pharmacy, University of Mosul, Mosul 41002, Iraq
  • 5 Neuroscience and Ophthalmology, Institute of Inflammation and Ageing, College of Medical and Dental Sciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK
  • 6 Department of Biochemistry and Molecular Biology, Cumming School of Medicine, University of Calgary, Calgary, AB T2N 4Z6, Canada
  • 7 Department of Biological Sciences, University of Calgary, Calgary, AB T2N 4N1, Canada
  • 8 Department of Clinical Laboratory Science, College of Applied Medical Science, Shaqra University, Shaqra, Saudi Arabia
  • 9 Department of Biochemistry and Structural Biology, Lund University, PO Box 124, 221 00 Lund, Sweden
  • 10 Department of Biomedical Sciences, University of Copenhagen, 2200 Copenhagen, Denmark
  • 11 Department of Experimental Medical Science, Lund University, PO Box 118, 221 00 Lund, Sweden
  • 12 School of Sciences, Research Institute in Healthcare Science, University of Wolverhampton, Wolverhampton WV1 1LY, UK
  • 13 Institute of Clinical Sciences, College of Medical and Dental Sciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK
Type
Published Article
Journal
Cell
Publisher
Cell Press
Publication Date
May 14, 2020
Volume
181
Issue
4
Pages
784–799
Identifiers
DOI: 10.1016/j.cell.2020.03.037
PMID: 32413299
PMCID: PMC7242911
Source
PubMed Central
Keywords
License
Unknown

Abstract

Modulating the subcellular localization of the water channel protein AQP4 may be a therapeutic option for treatment of brain and spinal cord edemas.

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