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Targeting ADP-ribosylation as an antimicrobial strategy.

Authors
  • Catara, Giuliana1
  • Corteggio, Annunziata1
  • Valente, Carmen1
  • Grimaldi, Giovanna1
  • Palazzo, Luca2
  • 1 Institute of Protein Biochemistry, National Research Council of Italy, Via Pietro Castellino 111, Naples 80131, Italy. , (Italy)
  • 2 Institute of Protein Biochemistry, National Research Council of Italy, Via Pietro Castellino 111, Naples 80131, Italy. Electronic address: [email protected] , (Italy)
Type
Published Article
Journal
Biochemical pharmacology
Publisher
New York, NY : Elsevier Science Inc
Publication Date
Sep 01, 2019
Volume
167
Pages
13–26
Identifiers
DOI: 10.1016/j.bcp.2019.06.001
PMID: 31176616
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

ADP-ribosylation (ADPr) is an ancient reversible modification of cellular macromolecules controlling major biological processes as diverse as DNA damage repair, transcriptional regulation, intracellular transport, immune and stress responses, cell survival and proliferation. Furthermore, enzymatic reactions of ADPr are central in the pathogenesis of many human diseases, including infectious conditions. By providing a review of ADPr signalling in bacterial systems, we highlight the relevance of this chemical modification in the pathogenesis of human diseases depending on host-pathogen interactions. The post-antibiotic era has raised the need to find alternative approaches to antibiotic administration, as major pathogens becoming resistant to antibiotics. An in-depth understanding of ADPr reactions provides the rationale for designing novel antimicrobial strategies for treatment of infectious diseases. In addition, the understanding of mechanisms of ADPr by bacterial virulence factors offers important hints to improve our knowledge on cellular processes regulated by eukaryotic homologous enzymes, which are often involved in the pathogenesis of human diseases. Copyright © 2019 Elsevier Inc. All rights reserved.

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