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Targeted treatments in colorectal cancer: state of the art and future perspectives.

Authors
  • Arnold, Dirk
  • Seufferlein, Thomas
Type
Published Article
Journal
Gut
Publisher
BMJ
Publication Date
Jun 01, 2010
Volume
59
Issue
6
Pages
838–858
Identifiers
DOI: 10.1136/gut.2009.196006
PMID: 20551469
Source
Medline
License
Unknown

Abstract

Targeted treatments have generated a lot of hope and hype in the treatment of gastrointestinal tumours. Indeed, the introduction of targeted treatments particularly for colorectal cancer has resulted in substantial improvements in tumour response and progression-free survival of patients. However, it is not fully understood how these agents act in patients, and the preclinical models are not appropriate to predict clinical efficacy. Here the current state of targeted treatments in colorectal cancer is reviewed, focusing on antiepidermal growth factor receptor (EGFR) and antiangiogenic strategies, describing how these agents fit into the therapeutic algorithm of this disease and discussing current understanding of the mechanism of action, biomarkers as well as future therapeutic strategies targeting multiple signalling pathways in colorectal cancer.

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