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Targeted Sequencing and Immunological Analysis Reveal the Involvement of Primary Immunodeficiency Genes in Pediatric IBD: a Japanese Multicenter Study.

Authors
  • Suzuki, Tasuku1
  • Sasahara, Yoji2
  • Kikuchi, Atsuo1
  • Kakuta, Humihiko3
  • Kashiwabara, Toshihiko4
  • Ishige, Takashi5
  • Nakayama, Yoshiko6
  • Tanaka, Masanori7
  • Hoshino, Akihiro8, 9
  • Kanegane, Hirokazu9
  • Abukawa, Daiki3
  • Kure, Shigeo1
  • 1 Department of Pediatrics, Tohoku University Graduate School of Medicine, 1-1 Seiryo-machi, Aoba-ku, Sendai, Miyagi, 980-8574, Japan. , (Japan)
  • 2 Department of Pediatrics, Tohoku University Graduate School of Medicine, 1-1 Seiryo-machi, Aoba-ku, Sendai, Miyagi, 980-8574, Japan. [email protected] , (Japan)
  • 3 Department of General Pediatrics, Miyagi Children's Hospital, Sendai, Miyagi, Japan. , (Japan)
  • 4 Department of Gastroenterology, Yamagata Prefectural Central Hospital, Yamagata, Japan. , (Japan)
  • 5 Department of Pediatrics, Gunma University Graduate School of Medicine, Gunma, Japan. , (Japan)
  • 6 Department of Pediatrics, Shinshu University School of Medicine, Nagano, Japan. , (Japan)
  • 7 Department of Pathology and Laboratory Medicine, Hirosaki City Hospital, Aomori, Japan. , (Japan)
  • 8 Department of Pediatrics, Toyama University School of Medicine, Toyama, Japan. , (Japan)
  • 9 Department of Pediatrics, Faculty of Medicine, Tokyo Medical and Dental University, Tokyo, Japan. , (Japan)
Type
Published Article
Journal
Journal of Clinical Immunology
Publisher
Springer-Verlag
Publication Date
Jan 01, 2017
Volume
37
Issue
1
Pages
67–79
Identifiers
DOI: 10.1007/s10875-016-0339-5
PMID: 27747465
Source
Medline
Keywords
License
Unknown

Abstract

Targeted sequencing and immunological analysis are useful for screening monogenic disorders and selecting curative therapies in pediatric patients with IBD. The genes responsible for PID are frequently involved in pediatric IBD and play critical roles in normal immune homeostasis in the gastrointestinal tract.

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