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Targeted sequencing identifies genetic polymorphisms of flavin-containing monooxygenase genes contributing to susceptibility of nicotine dependence in European American and African American.

Authors
  • Zhang, Tian-Xiao1
  • Saccone, Nancy L2
  • Bierut, Laura J1
  • Rice, John P1
  • 1 Department of PsychiatryWashington University School of MedicineSt. LouisMOUSA.
  • 2 Department of GeneticsWashington University School of MedicineSt. LouisMOUSA.
Type
Published Article
Journal
Brain and behavior
Publication Date
Apr 01, 2017
Volume
7
Issue
4
Identifiers
DOI: 10.1002/brb3.651
PMID: 28413702
Source
Medline
Keywords
License
Unknown

Abstract

Our findings indicated significant association between FMO genes and nicotine dependence. Replications of our findings in other ethnic groups were needed in the future. Most of the significant variants identified were SNPs located within intronic regions or with unknown functional significance, indicating a need for future work to understand the underlying functional significance of these signals.

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