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Targeted drug delivery for brain cancer treatment.

Authors
  • Gutman, R L
  • Peacock, G
  • Lu, D R
Type
Published Article
Journal
Journal of Controlled Release
Publisher
Elsevier
Publication Date
Mar 01, 2000
Volume
65
Issue
1-2
Pages
31–41
Identifiers
PMID: 10699267
Source
Medline
License
Unknown

Abstract

The blood brain barrier (BBB) and the systemic toxicity of conventional chemotherapy present obstacles to the success of future blood-borne drug therapies of brain tumors. The work with polymer-encapsulated cancer drugs suggests an alternative and more focused treatment approach. Our experimental strategy integrates direct intracerebral drug delivery, sustained drug release from liposomes or polymer implants, and increased targeting of the drug either by chemically modifying the drug or by using tumor-specific carriers. This review will present some of the recent work on targeted drug delivery for brain cancer treatment.

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