Affordable Access

Access to the full text

Taming the Heterogeneity of Aggressive Lymphomas for Precision Therapy

Authors
  • Young, Ryan M.
  • Phelan, James D.
  • Shaffer, Arthur L. III
  • Wright, George W.
  • Huang, Da Wei
  • Schmitz, Roland
  • Johnson, Calvin
  • Oellerich, Thomas
  • Wilson, Wyndham
  • Staudt, Louis M.
Type
Published Article
Journal
Annual Review of Cancer Biology
Publisher
Annual Reviews
Publication Date
Mar 04, 2019
Volume
3
Pages
429–455
Identifiers
DOI: 10.1146/annurev-cancerbio-030518-055734
Source
Annual Reviews
Keywords
License
Yellow

Abstract

Genomic analyses of diffuse large B cell lymphoma (DLBCL) are revealing the genetic and phenotypic heterogeneity of these aggressive lymphomas. In part, this heterogeneity reflects the existence of distinct genetic subtypes that acquire characteristic constellations of somatic genetic alterations to converge on the DLBCL phenotype. In parallel, functional genomic screens and proteomic analyses have identified multiprotein assemblies that coordinate oncogenic survival signaling in DLBCL. In this review, we merge these recent insights into a unified conceptual framework with implications for the design of precision medicine trials in DLBCL.

Report this publication

Statistics

Seen <100 times