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A TAD closer to ATM.

Authors
  • Aymard, Francois1
  • Legube, Gaëlle1
  • 1 LBCMCP, Center for Integrative Biology (CBI), Université de Toulouse, UT3, Toulouse, France; LBCMCP, Center for Integrative Biology (CBI), CNRS, Toulouse, France. , (France)
Type
Published Article
Journal
Molecular & Cellular Oncology
Publisher
Landes Bioscience
Publication Date
May 01, 2016
Volume
3
Issue
3
Identifiers
DOI: 10.1080/23723556.2015.1134411
PMID: 27314089
Source
Medline
Keywords
License
Unknown

Abstract

Ataxia telangiectasia mutated (ATM) has been known for decades as the main kinase mediating the DNA double-strand break response. Our recent findings suggest that its major role at the sites of breaks likely resides in its ability to modify both the local chromatin landscape and the global chromosome organization in order to promote repair accuracy.

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