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Tacrolimus pharmacokinetics in the early post-liver transplantation period and clinical applicability via Bayesian prediction.

Authors
  • Oteo, Itziar
  • Lukas, John C
  • Leal, Nerea
  • Suarez, Elena
  • Valdivieso, Andres
  • Gastaca, Mikel
  • Ortiz de Urbina, Jorge
  • Calvo, Rosario
Type
Published Article
Journal
European Journal of Clinical Pharmacology
Publisher
Springer-Verlag
Publication Date
Jan 01, 2013
Volume
69
Issue
1
Pages
65–74
Identifiers
DOI: 10.1007/s00228-012-1300-z
PMID: 22660442
Source
Medline
License
Unknown

Abstract

For TAC therapy, covariate models using mixed effects methods are most useful when combined with patient-specific biochemical assays as well as clinical evidence. In such cases, the observed C(min) and Bayes methods can provide the most likely individual PK parameters, hence the optimal next dose to reach individualized target levels for each patient.

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