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Tackling SARS-CoV-2: proposed targets and repurposed drugs.

Authors
  • Joshi, Siddhi1
  • Joshi, Maithili1
  • Degani, Mariam S1
  • 1 Department of Pharmaceutical Sciences & Technology, Institute of Chemical Technology, Nathalal Parekh Marg, Mumbai, 400019, Maharashtra, India. , (India)
Type
Published Article
Journal
Future Medicinal Chemistry
Publisher
"Future Science, LTD"
Publication Date
Sep 01, 2020
Volume
12
Issue
17
Pages
1579–1601
Identifiers
DOI: 10.4155/fmc-2020-0147
PMID: 32564623
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

The SARS-CoV-2 pandemic, declared as a global health emergency by the WHO in February 2020, has currently infected more than 6 million people with fatalities near 371,000 and increasing exponentially, in absence of vaccines and drugs. The pathogenesis of SARS-CoV-2 is still being elucidated. Identifying potential targets and repurposing drugs as therapeutic options is the need of the hour. In this review, we focus on potential druggable targets and suitable therapeutics, currently being explored in clinical trials, to treat SARS-CoV-2 infection. A brief understanding of the complex interactions of both viral as well as host targets, and the possible repurposed drug candidates are described with an emphasis on understanding the mechanisms at the molecular level.

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