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T1ρ-weighted Dynamic Glucose-enhanced MR Imaging in the Human Brain.

Authors
  • Paech, Daniel1
  • Schuenke, Patrick1
  • Koehler, Christina1
  • Windschuh, Johannes1
  • Mundiyanapurath, Sibu1
  • Bickelhaupt, Sebastian1
  • Bonekamp, David1
  • Bäumer, Philipp1
  • Bachert, Peter1
  • Ladd, Mark E1
  • Bendszus, Martin1
  • Wick, Wolfgang1
  • Unterberg, Andreas1
  • Schlemmer, Heinz-Peter1
  • Zaiss, Moritz1
  • Radbruch, Alexander1
  • 1 From the Divisions of Radiology (D.P., C.K., S.B., D.B., P. Bäumer, H.P.S., M.Z., A.R.) and Medical Physics in Radiology (P.S., J.W., P. Bachert, M.E.L.), German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120 Heidelberg, Germany; Departments of Neuroradiology (C.K., M.B., A.R.), Neurology (S.M., W.W.), and Neurosurgery (A.U.), University Hospital Heidelberg, Heidelberg, Germany; Faculty of Physics and Astronomy and Faculty of Medicine, University of Heidelberg, Heidelberg, Germany (M.E.L.); and Max-Planck-Institute for Biological Cybernetics, Tuebingen, Germany (M.Z.). , (Germany)
Type
Published Article
Journal
Radiology
Publisher
Radiological Society of North America
Publication Date
Dec 01, 2017
Volume
285
Issue
3
Pages
914–922
Identifiers
DOI: 10.1148/radiol.2017162351
PMID: 28628422
Source
Medline
License
Unknown

Abstract

Purpose To evaluate the ability to detect intracerebral regions of increased glucose concentration at T1ρ-weighted dynamic glucose-enhanced (DGE) magnetic resonance (MR) imaging at 7.0 T. Materials and Methods This prospective study was approved by the institutional review board. Nine patients with newly diagnosed glioblastoma and four healthy volunteers were included in this study from October 2015 to July 2016. Adiabatically prepared chemical exchange-sensitive spin-lock imaging was performed with a 7.0-T whole-body unit with a temporal resolution of approximately 7 seconds, yielding the time-resolved DGE contrast. T1ρ-weighted DGE MR imaging was performed with injection of 100 mL of 20% d-glucose via the cubital vein. Glucose enhancement, given by the relative signal intensity change at T1ρ-weighted MR imaging (DGEρ), was quantitatively investigated in brain gray matter versus white matter of healthy volunteers and in tumor tissue versus normal-appearing white matter of patients with glioblastoma. The median signal intensities of the assessed brain regions were compared by using the Wilcoxon rank-sum test. Results In healthy volunteers, the median signal intensity in basal ganglia gray matter (DGEρ = 4.59%) was significantly increased compared with that in white matter tissue (DGEρ = 0.65%) (P = .028). In patients, the median signal intensity in the glucose-enhanced tumor region as displayed on T1ρ-weighted DGE images (DGEρ = 2.02%) was significantly higher than that in contralateral normal-appearing white matter (DGEρ = 0.08%) (P < .0001). Conclusion T1ρ-weighted DGE MR imaging in healthy volunteers and patients with newly diagnosed, untreated glioblastoma enabled visualization of brain glucose physiology and pathophysiologically increased glucose uptake and may have the potential to provide information about glucose metabolism in tumor tissue. © RSNA, 2017 Online supplemental material is available for this article.

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