Affordable Access

Access to the full text

T Cell Specificity: A Great Challenge in Chagas Disease

Authors
  • Ferragut, Fátima
  • Acevedo, Gonzalo R.
  • Gómez, Karina A.
Type
Published Article
Journal
Frontiers in Immunology
Publisher
Frontiers Media SA
Publication Date
Jun 29, 2021
Volume
12
Identifiers
DOI: 10.3389/fimmu.2021.674078
Source
Frontiers
Keywords
Disciplines
  • Immunology
  • Review
License
Green

Abstract

The CD4+ and CD8+ T cell immune response against T. cruzi, the parasite causing Chagas disease, are relevant for both parasite control and disease pathogenesis. Several studies have been focused on their phenotype and functionally, but only a few have drilled down to identify the parasite proteins that are processed and presented to these cells, especially to CD4+ T lymphocytes. Although approximately 10,000 proteins are encoded per haploid T. cruzi genome, fewer than 200 T cell epitopes from 49 T. cruzi proteins have been identified so far. In this context, a detailed knowledge of the specific targets of T cell memory response emerges as a prime tool for the conceptualization and development of prophylactic or therapeutic vaccines, an approach with great potential to prevent and treat this chronic disease. Here, we review the available information about this topic in a comprehensive manner and discuss the future challenges in the field.

Report this publication

Statistics

Seen <100 times