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T-cell specific immunosuppression by prodigiosin isolated from Serratia marcescens.

Authors
  • Han, S B
  • Kim, H M
  • Kim, Y H
  • Lee, C W
  • Jang, E S
  • Son, K H
  • Kim, S U
  • Kim, Y K
Type
Published Article
Journal
International Journal of Immunopharmacology
Publisher
Elsevier
Publication Date
Jan 01, 1998
Volume
20
Issue
1-3
Pages
1–13
Identifiers
PMID: 9717078
Source
Medline
License
Unknown

Abstract

Prodigiosin was isolated from the culture broth of Serratia marcescens B-1231. This compound inhibited the T-cell mediated immune responses such as concanavalin-A induced proliferation, mixed lymphocyte response, local graft vs host reaction and T-dependent antibody response at non-toxic concentrations. However, prodigiosin did not affect B-cell mediated immune functions such as lipopolysaccharide-induced proliferation and-activated polyclonal antibody production at the same concentrations. Prodigiosin did not cause death in vitro to lymphocytes at effective concentrations (< 100 nM) and also did not show toxicity in vivo to lymphoid organs at effective dosages (10 and 30 mg/kg). The pharmacological potencies were comparable to the activities of other T-cell specific immunosuppressants such as cyclosporin A and FK-506. In conclusion, it might be suggested that prodigiosin could be used as an immunosuppressant in clinical and immunological studies.

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