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T-cell-rich B-cell lymphoma of the spleen presenting with severe hypersplenism.

Authors
  • Dincol, G
  • Agan, M
  • Dogan, O
  • Diz-Kucukkaya, R
  • Uslu, B
Type
Published Article
Journal
Clinical and laboratory haematology
Publication Date
Dec 01, 2006
Volume
28
Issue
6
Pages
419–422
Identifiers
PMID: 17105497
Source
Medline
License
Unknown

Abstract

We report a 19-year-old woman who was presented with B-symptoms, massive splenomegaly, hepatomegaly and hypersplenism. She underwent diagnostic/therapeutic splenectomy. Microscopically, the spleen showed a vaguely micronodular and diffuse proliferation of lymphoid cells in the white pulp that also involved the red pulp. On immunohistochemical staining, this proliferation consisted predominantly of CD3(+), CD7(+) small T cells with the presence of a minor population of CD15(-),CD30(-), CD20(+) large atypical B cells. A liver biopsy also showed a similar morphology to that seen in the spleen. After splenectomy, only the pancytopenia improved. A combined immunochemotherapy regimen (rituximab, cyclophosphamide, doxorubicin, vincristine and prednisolone) was utilized, which resulted in a complete remission.

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