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T- and B-lymphocyte subpopulations in the tropical splenomegaly syndrome (TSS).

Authors
  • Fakunle, Y M
  • Oduloju, A J
  • Greenwood, B M
Type
Published Article
Journal
Clinical and experimental immunology
Publication Date
Aug 01, 1978
Volume
33
Issue
2
Pages
239–243
Identifiers
PMID: 309810
Source
Medline
License
Unknown

Abstract

Lymphocyte subpopulations in thirty-nine patients with the tropical splenomegaly syndrome (TSS) were studied using the E-rosette, EAC rosette and direct immunofluorescent staining techniques. In the peripheral blood a decrease in the percentage of T-lymphocytes was found which was accompanied by an increase in the percentage and number of B-lymphocytes. These abnormalities reverted towards normal on treatment. Splenic aspirates contained an increased proportion of T-lymphocytes. The relative T-cell lymphoenia in TSS is probably due to specific trapping or non-specific sequestration of lymphocytes in the liver and splen. B-cell lymphocytosis is probably due to persistent antigenic or mitogenic stimulation by malaria.

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