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Systolic blood pressure, routine kidney variables and renal ultrasonographic findings in cats naturally infected with feline immunodeficiency virus

Authors
  • Taffin, Elien
  • Paepe, Dominique
  • Ghys, Liesbeth
  • De Roover, Katrien
  • Van de Maele, Isabel
  • Saunders, Jimmy
  • Duchateau, Luc
  • Daminet, Sylvie
Publication Date
Jan 01, 2017
Source
Ghent University Institutional Archive
Keywords
Language
English
License
Unknown
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Abstract

Objectives: Hypertension is a common cause of proteinuria in HIV-infected people. In cats, feline immunodeficiency virus (FIV) infection appears to be associated with proteinuria. Therefore, the results from systolic blood pressure (SBP) measurements in naturally infected FIV-positive cats were reviewed to assess whether hypertension contributes to the observed proteinuria in these cats. Ultrasonographic findings in FIV-positive cats were reviewed to complete renal assessment and to extend the scant knowledge on renal ultrasonography in cats. Methods: Data from client-owned, naturally infected FIV-positive cats were retrospectively reviewed. To obtain a control group, records were reviewed from age-matched, privately owned, FIV-negative cats. Results: Data from 91 FIV-infected and 113 control cats were compared. FIV-infected cats showed a significantly lower SBP (P <0.0001) and significantly fewer FIV-infected cats were hypertensive (160 mmHg) compared with control cats (P = 0.025). The prevalence of renal azotaemia did not significantly differ between groups, although FIV-infected cats had significantly lower urine specific gravity (USG) (P = 0.0273) and a higher incidence of USG below 1.035 (P = 0.043). Urinary protein:creatinine ratio (UPC) was significantly higher in FIV-infected cats (P = 0.0005) and proteinuria (UPC >0.4) occurred more frequently in FIV-infected cats (P <0.001). Renal ultrasonography showed abnormalities in 60/91 FIV-infected cats, with hyperechogenic cortices in 39/91 and enlarged kidneys in 31/91. Conclusions and relevance: Hypertension can be excluded as a common cause of renal damage leading to proteinuria in FIV-infected cats. Proteinuria and poorly concentrated urine are common in naturally infected FIV-positive cats, in contrast to azotaemia. Clinicians should cautiously interpret ultrasonographic abnormalities as these occur in over half of FIV-infected cats.

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