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Systemic autoimmunity induced by Toll-like receptor 7/8 agonist Resiquimod causes myocarditis and dilated cardiomyopathy: a new model of autoimmune heart disease

Authors
  • Hasham, MG
  • Baxan, N
  • Stuckey, D
  • Dent, O
  • Branca, J
  • Perkins, BRA
  • Duffy, T
  • Hameed, TS
  • Stella, SE
  • Bellahcene, M
  • Schneider, MD
  • Harding, SE
  • Rosenthal, N
  • Sattler, S
Publication Date
Jan 18, 2017
Source
Spiral - Imperial College Digital Repository
Keywords
License
Unknown
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Abstract

Systemic autoimmune diseases such as Systemic Lupus Erythematosus (SLE) and Rheumatoid Arthritis (RA) show significant heart involvement and cardiovascular morbidity, which can be due to systemically increased levels of inflammation or direct autoreactivity targeting cardiac tissue. Despite high clinical relevance, cardiac damage secondary to systemic autoimmunity lacks inducible rodent models. Here we characterize immune-mediated cardiac tissue damage in a new model of SLE induced by topical application of the TLR-7/8 agonist Resiquimod. We observe a cardiac phenotype reminiscent of autoimmune-mediated dilated cardiomyopathy, and identify auto-antibodies as major contributors to cardiac tissue damage. Resiquimod-induced heart disease is a highly relevant mouse model for mechanistic and therapeutic studies aiming to protect the heart during autoimmunity.

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