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Systemic absorption and persistence of tioconazole in vaginal fluid after insertion of a single 300-mg tioconazole ovule.

Authors
  • Houang, E T
  • Lawrence, A G
Type
Published Article
Journal
Antimicrobial agents and chemotherapy
Publication Date
Jun 01, 1985
Volume
27
Issue
6
Pages
964–965
Identifiers
PMID: 4026270
Source
Medline
License
Unknown

Abstract

After vaginal insertion of a 300-mg ovule of tioconazole in 10 patients with vaginal candidiasis, the mean concentration in plasma was 21.2 ng/ml (range, 10.6 to 35.8 ng/ml) at 8 h and was not measurable at 24 h in 9 of 10 patients. The mean vaginal concentration at 24 h was 21.4 mg/liter (range, 2.4 to 50 mg/liter) and remained detectable in 7 of 9 and 2 of 9 patients after 48 and 72 h, respectively.

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