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Systematic review on the value of end-of-treatment FDG-PET in improving overall survival of lymphoma patients.

Authors
  • Adams, Hugo J A1
  • Kwee, Thomas C2
  • 1 Department of Radiology and Nuclear Medicine, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105AZ, Amsterdam, Netherlands. [email protected] , (Netherlands)
  • 2 Department of Radiology and Nuclear Medicine, University Medical Center Groningen, University of Groningen, Groningen, Netherlands. , (Netherlands)
Type
Published Article
Journal
Annals of Hematology
Publisher
Springer-Verlag
Publication Date
Dec 07, 2019
Identifiers
DOI: 10.1007/s00277-019-03881-x
PMID: 31811361
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

This study aimed to systematically review the value of end-of-treatment 18F-fluoro-2-deoxy-D-glucose (FDG) positron emission tomography (PET) in improving overall survival (OS) of lymphoma patients. Medline was systematically searched for (1) randomized trials comparing the OS of patients who underwent end-of-treatment FDG-PET to those without and FDG-PET-based end-of-treatment evaluation and for (2) non-randomized studies comparing the OS of patients who underwent end-of-treatment FDG-PET to a (historical) cohort of patients without an FDG-PET-based end-of-treatment evaluation. The Medline search revealed 6284 articles. However, none of these reported data on the value of end-of-treatment FDG-PET in improving OS of lymphoma patients. In conclusion, the present systematic review reveals that there is currently no study at all that evaluates the value of end-of-treatment FDG-PET in improving OS of lymphoma patients. As a result, it remains unknown whether end-of-treatment FDG-PET increases OS and in which lymphoma subtype these examinations are of particular value. Future studies are required to demonstrate its value in this setting before it can be recommended as an evidence-based diagnostic tool by guidelines on the use of imaging in lymphoma.

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