The current situation in Spain has led to increase social inequalities in health in the population. Immigrants without economic resources are the most vulnerable group with high rates of morbidity and mortality. For this reason, the Commission on Social Determinants of Health (CSDH) was created by developing a conceptual framework to classify the inequality factors, and thus, politically designing actions in order to reduce this problem. The nursing professional collaboration in developing effective policies to reduce health inequalities would be a new framework, because this profession possesses unique knowledge of people who are cared with social problem. One of the main problems identified by nurses in the immigrant population is social isolation, being developed in this text one of the nursing diagnoses included in a immigrant person care plan with social inequality in health.