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Systematic Review: Does Balloon Pulmonary Angioplasty (BPA) Improve Right Ventricular Function in CTEPH Patients? Evaluation Based on Imaging Findings

Authors
  • Papadopoulou, V.1
  • Karyofyllis, P.1
  • Tsiapras, D.2
  • Demerouti, E.2
  • Kosmas, I.1
  • Voudris, V.1
  • 1 Onassis Cardiac Surgery Center, Sygrou Ave 356, Kallithea, Athens, 17674, Greece , Athens (Greece)
  • 2 Onassis Cardiac Surgery Centre, Athens, Greece , Athens (Greece)
Type
Published Article
Journal
Current Treatment Options in Cardiovascular Medicine
Publisher
Springer US
Publication Date
Oct 21, 2020
Volume
22
Issue
11
Identifiers
DOI: 10.1007/s11936-020-00839-5
Source
Springer Nature
Keywords
License
Yellow

Abstract

Purpose of reviewChronic thromboembolic pulmonary hypertension (CTEPH) is a life-threatening disease with many complications, such as right heart failure. Therefore, a direct and efficient therapy is imperative. This review aims to determine the effectiveness of balloon pulmonary angioplasty (BPA) on right ventricular (RV) function among CTEPH patients, using imaging methods.Recent findingsFrom April 2019 to August 2019, PubMed database was searched for randomized control trials and cohort studies conducted until August 2019, evaluating the impact of BPA on RV function as assessed by non-invasive modalities. Data were extracted, and validity was assessed by 2 reviewers and graded using the Cochrane Collaboration tool for assessing a risk of bias. A total of 204 articles were screened for relevance. Only 14 articles were deemed eligible for this review, 4 studies being prospective and 10 retrospective trials. Totally 395 patients with CTEPH who underwent BPA enrolled. The findings indicated improvement in hemodynamic parameters and RV function.SummaryBPA is an effective and appropriate therapy for non-operable CTEPH patients leading to significant improvements in RV function. Two-dimensional and 3D echocardiography and cardiac magnetic resonance imaging (CMRI) are reliable non-invasive imaging methods for RV function assessment after BPA.

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