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A systematic approach for successful PCSK9 inhibitor prescribing in clinical practice.

Authors
  • Knickelbine, Thomas1
  • Jia, Lori2
  • White, Susan K2
  • Garberich, Ross F2
  • Oberembt, Sandra J2
  • Wills, Samantha2
  • Miedema, Michael D2
  • Brilakis, Emmanouil S2
  • 1 Minneapolis Heart Institute and Minneapolis Heart Institute Foundation, Minneapolis, MN, USA. Electronic address: [email protected]
  • 2 Minneapolis Heart Institute and Minneapolis Heart Institute Foundation, Minneapolis, MN, USA.
Type
Published Article
Journal
Journal of Clinical Lipidology
Publisher
Elsevier
Publication Date
Jan 01, 2019
Volume
13
Issue
2
Pages
265–271
Identifiers
DOI: 10.1016/j.jacl.2019.01.005
PMID: 30745203
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Despite patient and provider interest, the use of PCSK9i therapy remains limited in clinical practice. High annual listed prices have created intense payer scrutiny and frequent health plan denials, with national approval rates in the range of 30% to 40%. Our goal was to validate the strategies for increasing PCSK9i approval rates and to present a framework for successful PCSK9i prescribing in clinical practice. In Sept 2015, a systematic team-based approach was developed and implemented at our institution. The approach centered on a preventive team of 3 senior staff cardiologists, 1 nurse practitioner, 1 physician assistant, 1 care coordinator, 1 pharmacist, and 1 pharmacy technician. The team was responsible for gathering and compiling the required documents to support an approval, as well as collaborating with the in-house pharmacy to complete PA and appeals processes. In the total study population, 141 (71.9%) were approved for PCSK9i therapy at first submission and 55 (28.1%) were rejected. Of those initially rejected, 48 (85.7%) appealed and all 48 who appealed (100.0%) were ultimately approved. The final coverage decision was 189 (96.4%) approved and 7 (3.6%) rejected. Our study highlights the presence of modifiable barriers in the PCSK9i approval process. Given the crucial role of health care teams in overcoming these modifiable barriers, we developed a simple stepwise algorithm for navigating the PCSK9i approval process. Our algorithm can help relieve busy providers of heavy administrative burdens and facilitate greater accuracy, standardization, and efficiency in documentation. Copyright © 2019 National Lipid Association. Published by Elsevier Inc. All rights reserved.

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